Anal Cancer Screening: A 10 Year Experience

E13   |  10 min   |   Latest   |  Publication Source   

• Podcast based on: Espirito Santo I, Kefleyesus A, Chilou C, Faes S, Clerc D, Hübner M, Hahnloser D, Grass F. Anal Cancer Screening: 10-Year Experience of a Specialized Outpatient Clinic. Cancers. 2025; 17(2):193. https://doi.org/10.3390/cancers17020193
  Type: Article  |  Publication date: Jan 9, 2025
  
  
• Summary: This ten-year longitudinal study from Lausanne University Hospital analysed 537 patients attending a high-resolution anoscopy (HRA) clinic for anal cancer screening. Almost half presented with dysplastic lesions, mostly low-grade, with only a small percentage progressing to more serious conditions. High-risk HPV genotypes, detectable HIV viral load, and initial symptoms were identified as independent risk factors for advanced precancerous lesions. While no patients progressed to invasive cancer during follow-up, the findings highlight the importance of regular screening and early intervention, particularly in high-risk groups, to prevent anal cancer progression. The study also resulted in a refined institutional screening algorithm.
  
  
• Keywords: anal cancer; high-resolution anoscopy; HPV testing; anal dysplasia; screening; algorithm; HIV; MSM

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