Tumor Dormancy: Clinical Opportunities and Challenges

E16   |  16 min   |   Latest   |  Publication Source   

• Podcast based on: Boydell E, Borgeaud M, Tsantoulis P. Dormant Tumor Cells: Current Opportunities and Challenges in Clinical Practice. Onco. 2025; 5(1):3. https://doi.org/10.3390/onco5010003
  Type: Review  |  Publication date: Jan 10, 2025
  
  
• Summary: This research review examines dormant tumour cells, cells that remain inactive after cancer treatment, potentially causing relapse. It explores the molecular mechanisms underlying dormancy, the role of the immune system and microenvironment, and the challenges in detecting these cells clinically. The review also discusses potential therapeutic strategies, including maintaining dormancy, eradicating dormant cells, and targeting the tumour's niche, highlighting the complexities and limitations of current approaches. Finally, it emphasises the need for clinically meaningful endpoints in future trials focusing on dormant tumour cells.
  
  
• Keywords: disseminated tumor cells; dormancy; minimal residual disease; breast cancer

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